Gating pluripotency via nuclear pores

Trends Mol Med. 2014 Jan;20(1):1-7. doi: 10.1016/j.molmed.2013.10.003. Epub 2013 Nov 7.


In recent years, growing evidence has pointed to the interesting idea that pluripotency might be regulated by a nuclear-pore-coordinated network that controls the level of pluripotency factors in the nucleus. A thorough understanding of this process might improve our comprehension of cell pluripotency and differentiation during embryogenesis, as well as aiding the development of novel models for studying human diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Active Transport, Cell Nucleus
  • Animals
  • Cell Differentiation*
  • Cell Nucleus / metabolism
  • Embryonic Development / physiology
  • Humans
  • Nuclear Pore / physiology*
  • Protein Binding
  • Protein Processing, Post-Translational
  • Protein Transport