A parallel randomized trial on the effect of a healthful diet on inflammageing and its consequences in European elderly people: design of the NU-AGE dietary intervention study

Mech Ageing Dev. 2013 Nov-Dec;134(11-12):523-30. doi: 10.1016/j.mad.2013.10.002. Epub 2013 Nov 5.


Background: The proportion of European elderly is expected to increase to 30% in 2060. Combining dietary components may modulate many processes involved in ageing. So, it is likely that a healthful diet approach might have greater favourable impact on age-related decline than individual dietary components. This paper describes the design of a healthful diet intervention on inflammageing and its consequences in the elderly.

Methods: The NU-AGE study is a parallel randomized one-year trial in 1250 apparently healthy, independently living European participants aged 65-80 years. Participants are randomised into either the diet group or control group. Participants in the diet group received dietary advice aimed at meeting the nutritional requirements of the ageing population. Special attention was paid to nutrients that may be inadequate or limiting in diets of elderly, such as vitamin D, vitamin B12, and calcium. C-reactive protein is measured as primary outcome.

Discussion: The NU-AGE study is the first dietary intervention investigating the effect of a healthful diet providing targeted nutritional recommendations for optimal health and quality of life in apparently healthy European elderly. Results of this intervention will provide evidence on the effect of a healthful diet on the prevention of age related decline.

Keywords: Ageing; Elderly; Intervention; Nutrition.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging*
  • C-Reactive Protein / metabolism
  • Calcium / metabolism
  • Diet*
  • Europe
  • Female
  • Humans
  • Inflammation*
  • Male
  • Quality of Life
  • Surveys and Questionnaires
  • Systems Biology
  • Time Factors
  • Treatment Outcome
  • Vitamin B 12 / metabolism
  • Vitamin D / metabolism


  • Vitamin D
  • C-Reactive Protein
  • Vitamin B 12
  • Calcium