Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus

Nat Neurosci. 2013 Dec;16(12):1728-30. doi: 10.1038/nn.3572. Epub 2013 Nov 10.

Abstract

Using immunohistology, electron microscopy, electrophysiology and optogenetics, we found that proliferating adult mouse hippocampal neural precursors received immature GABAergic synaptic inputs from parvalbumin-expressing interneurons. Recently shown to suppress adult quiescent neural stem cell activation, parvalbumin interneuron activation promoted newborn neuronal progeny survival and development. Our results suggest a niche mechanism involving parvalbumin interneurons that couples local circuit activity to the diametric regulation of two critical early phases of adult hippocampal neurogenesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult Stem Cells / physiology*
  • Animals
  • Animals, Newborn
  • Cell Survival
  • Hippocampus / cytology*
  • Hippocampus / growth & development
  • Interneurons / metabolism*
  • Interneurons / ultrastructure
  • Luminescent Proteins / genetics
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Mice
  • Mice, Inbred C57BL
  • Microtubule-Associated Proteins / metabolism
  • Nerve Net / metabolism*
  • Nerve Tissue Proteins / metabolism
  • Neurogenesis / genetics
  • Neurogenesis / physiology*
  • Neuropeptides / metabolism
  • Phenylurea Compounds
  • Phosphoproteins / genetics
  • Phosphoproteins / metabolism*
  • Transduction, Genetic

Substances

  • Luminescent Proteins
  • Membrane Proteins
  • Microtubule-Associated Proteins
  • Nerve Tissue Proteins
  • Neuropeptides
  • Palm protein, mouse
  • Phenylurea Compounds
  • Phosphoproteins
  • doublecortin protein
  • ethylene diurea