PAG--a multipurpose transmembrane adaptor protein

Oncogene. 2014 Oct 9;33(41):4881-92. doi: 10.1038/onc.2013.485. Epub 2013 Nov 11.


Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), also known as Csk-binding protein (Cbp), is a ubiquitously expressed transmembrane adaptor protein present in lipid rafts and involved in a number of signaling pathways. It helps recruit cytoplasmic C-terminal Src kinase (Csk) to lipid raft-associated Src kinases, mediates a link to actin cytoskeleton and interacts with several other important cytoplasmic and plasma membrane-associated proteins. In recent years, PAG has been implicated in various aspects of cancer cell biology. Our review covers all so far published data on this interesting protein.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actin Cytoskeleton / metabolism
  • Animals
  • CSK Tyrosine-Protein Kinase
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Membrane Microdomains / metabolism*
  • Membrane Proteins / chemistry
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Neoplasms / metabolism
  • Phosphorylation
  • Signal Transduction
  • src-Family Kinases / metabolism*


  • Membrane Proteins
  • CSK Tyrosine-Protein Kinase
  • src-Family Kinases
  • CSK protein, human