Celiac disease and endocrine autoimmune disorders in children: an update

Expert Rev Clin Immunol. 2013 Dec;9(12):1289-301. doi: 10.1586/1744666X.2013.850029.


Celiac disease (CD) is a life-long inflammatory condition of the gut that occurs in genetically susceptible individuals. Several autoimmune diseases (AI) are associated with CD. To date, no conclusive evidence is available that proves if the relationship between CD and AI is mediated by gluten exposure, or if CD and AI could co-occur due to other causes, in particular the loss of the intestinal barrier function and the common genetic background. Furthermore, it is not clear yet if CD needs a regular screening program for AI. This review will cover the key studies on both the pathogenetic and clinical evidence explaining this association. We will review the reports including patients aged <18 years with CD and endocrine AI.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Animals
  • Autoimmune Diseases / epidemiology*
  • Autoimmune Diseases / genetics
  • Autoimmune Diseases / immunology
  • Autoimmunity
  • Celiac Disease / epidemiology*
  • Celiac Disease / genetics
  • Celiac Disease / immunology
  • Child
  • Child, Preschool
  • Endocrine System Diseases / epidemiology*
  • Endocrine System Diseases / genetics
  • Endocrine System Diseases / immunology
  • Genetic Predisposition to Disease
  • Humans
  • Infant
  • Infant, Newborn
  • Intestines / immunology*
  • Intestines / pathology
  • Risk Factors