Canine oral mucosal mast cell tumours

Vet Comp Oncol. 2016 Mar;14(1):101-11. doi: 10.1111/vco.12071. Epub 2013 Nov 11.


Mast cell tumours (MCTs) are the most common cutaneous tumours of dogs, however rarely they can arise from the oral mucosa. This subset of MCT is reported to demonstrate a more aggressive clinical course than those tumours on the haired skin and the authors hypothesised that dogs with oral, mucosal MCT would have a high incidence of local lymph node metastasis at presentation and that this would be a negative prognostic factor. An additional hypothesis was that mitotic index (MI) would be prognostic. This retrospective study examines 33 dogs with MCTs arising from the oral mucosa. The results suggest that oral mucosal MCTs in the dog have a high incidence of lymph node metastasis at diagnosis (55%) which results in a poor prognosis. MI and nodal metastasis is highly prognostic. Loco-regional progression is common in these patients and dogs with adequate local control of their tumour had an improved outcome. Despite a more aggressive clinical course, treatment can result in protracted survivals, even when metastasis is present.

Keywords: chemotherapy; oncology; radiation oncology; small animal; surgical oncology; tumour biology; tyrosine kinase.

MeSH terms

  • Animals
  • Disease Progression
  • Dog Diseases / pathology*
  • Dogs
  • Female
  • Lymph Nodes
  • Male
  • Mastocytoma / pathology
  • Mastocytoma / veterinary*
  • Mouth Neoplasms / pathology
  • Mouth Neoplasms / veterinary*
  • Retrospective Studies
  • Survival Analysis