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Case Reports
. 2014 Jan:234:e14-20.
doi: 10.1016/j.forsciint.2013.10.015. Epub 2013 Oct 18.

Postmortem detection of 25I-NBOMe [2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine] in fluids and tissues determined by high performance liquid chromatography with tandem mass spectrometry from a traumatic death

Justin L Poklis  1 , Kelly G Devers  2 , Elise F Arbefeville  2 , Julia M Pearson  2 , Eric Houston  3 , Alphonse Poklis  4
Affiliations
Case Reports

Postmortem detection of 25I-NBOMe [2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine] in fluids and tissues determined by high performance liquid chromatography with tandem mass spectrometry from a traumatic death

Justin L Poklis et al. Forensic Sci Int. 2014 Jan.

Abstract

We present a traumatic fatality of a 19-year-old man who had ingested blotter paper containing 25I-NBOMe [2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine]. Postmortem specimens were analyzed by high performance liquid chromatography with tandem mass spectrometry (HPLC/MS/MS). Toxicology findings for fluids based upon blood or urine calibrators were as follows: peripheral blood, 405 pg/mL; heart blood, 410 pg/mL; urine, 2.86 ng/mL; and vitreous humor, 99 pg/mL. While findings based upon the method of standard additions were: gastric contents, 7.1 μg total; bile, 10.9 ng/g; brain, 2.54 ng/g and liver, 7.2 ng/g. To our knowledge the presented case is the first postmortem case of 25I-NBOMe intoxication documented by toxicological analysis of tissues and body fluids.

Keywords: 25I-NBOMe; Bath salts; Designer drugs; HPLC/MS/MS.

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Figures

Fig. 1
Fig. 1
Chemical structure of 25I-NBOMe.
Fig. 2
Fig. 2
Chromatographic separation of 25I-NBOMe and 25H-NBOMe.
Fig. 3
Fig. 3
Standard addition curves.
See this image and copyright information in PMC

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