Non-paraneoplastic voltage-gated calcium channels antibody-mediated cerebellar ataxia responsive to IVIG treatment

J Neurol Sci. 2014 Jan 15;336(1-2):169-70. doi: 10.1016/j.jns.2013.10.031. Epub 2013 Oct 29.


Non-paraneoplastic cerebellar ataxia associated with voltage-gated calcium channel (VGCC) antibodies is a rare entity with only few cases reported in literature. We describe a 60 year-old man with subacute cerebellar ataxia and subclinical Lambert-Eaton myasthenic syndrome (LEMS) in whom VGCC antibodies were detected at high titer in serum and cerebrospinal fluid. Screening for underlying malignancies was negative. Intravenous immunoglobulin treatment led to the improvement of clinical picture and reduction of serum antibody titer over a 13-month follow-up period. We emphasize that VGCC antibodies should be included in the diagnostic work-up of patients with subacute cerebellar ataxia and that treatment with IVIG can improve the clinical picture and prevent disability.

Keywords: Antibodies; Cerebellar ataxia; Eaton-Lambert myasthenic syndrome; Intravenous immunoglobulin; Voltage-gated calcium channels; immuno-mediated ataxia.

Publication types

  • Case Reports

MeSH terms

  • Autoantibodies / biosynthesis
  • Autoantibodies / blood*
  • Calcium Channels / blood*
  • Cerebellar Ataxia / blood*
  • Cerebellar Ataxia / diagnosis
  • Cerebellar Ataxia / drug therapy
  • Diagnosis, Differential
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use*
  • Lambert-Eaton Myasthenic Syndrome / blood*
  • Lambert-Eaton Myasthenic Syndrome / diagnosis
  • Lambert-Eaton Myasthenic Syndrome / drug therapy
  • Male
  • Middle Aged
  • Treatment Outcome


  • Autoantibodies
  • Calcium Channels
  • Immunoglobulins, Intravenous