A decade after SARS: strategies for controlling emerging coronaviruses

Nat Rev Microbiol. 2013 Dec;11(12):836-48. doi: 10.1038/nrmicro3143. Epub 2013 Nov 11.


Two novel coronaviruses have emerged in humans in the twenty-first century: severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), both of which cause acute respiratory distress syndrome (ARDS) and are associated with high mortality rates. There are no clinically approved vaccines or antiviral drugs available for either of these infections; thus, the development of effective therapeutic and preventive strategies that can be readily applied to new emergent strains is a research priority. In this Review, we describe the emergence and identification of novel human coronaviruses over the past 10 years, discuss their key biological features, including tropism and receptor use, and summarize approaches for developing broadly effective vaccines.

Publication types

  • Review

MeSH terms

  • Communicable Diseases, Emerging / epidemiology*
  • Communicable Diseases, Emerging / prevention & control*
  • Coronavirus / genetics
  • Coronavirus / isolation & purification*
  • Coronavirus / pathogenicity
  • Coronavirus / physiology
  • Coronavirus Infections / epidemiology*
  • Coronavirus Infections / prevention & control*
  • Drug Discovery / trends
  • Humans
  • Receptors, Virus / metabolism
  • Viral Tropism
  • Viral Vaccines / immunology
  • Viral Vaccines / isolation & purification


  • Receptors, Virus
  • Viral Vaccines