YB-1 protein: functions and regulation

Wiley Interdiscip Rev RNA. Jan-Feb 2014;5(1):95-110. doi: 10.1002/wrna.1200. Epub 2013 Nov 11.


The Y-box binding protein 1 (YB-1, YBX1) is a member of the family of DNA- and RNA-binding proteins with an evolutionarily ancient and conserved cold shock domain. It falls into a group of intrinsically disordered proteins that do not follow the classical rule 'one protein-one function' but introduce a novel principle stating that a disordered structure suggests many functions. YB-1 participates in a wide variety of DNA/RNA-dependent events, including DNA reparation, pre-mRNA transcription and splicing, mRNA packaging, and regulation of mRNA stability and translation. At the cell level, the multiple activities of YB-1 are manifested as its involvement in cell proliferation and differentiation, stress response, and malignant cell transformation. WIREs RNA 2014, 5:95-110. doi: 10.1002/wrna.1200 CONFLICT OF INTEREST: The authors have declared no conflicts of interest for this article. For further resources related to this article, please visit the WIREs website.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Cell Differentiation
  • Cell Proliferation
  • DNA / genetics
  • DNA / metabolism*
  • DNA Repair
  • Humans
  • Protein Biosynthesis
  • Protein Conformation
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism*
  • Stress, Physiological
  • Transcriptional Activation
  • Y-Box-Binding Protein 1 / chemistry
  • Y-Box-Binding Protein 1 / genetics
  • Y-Box-Binding Protein 1 / metabolism*


  • RNA, Messenger
  • Y-Box-Binding Protein 1
  • DNA