After the cure: management of HCV after achievement of SVR

Curr HIV/AIDS Rep. 2013 Dec;10(4):428-35. doi: 10.1007/s11904-013-0181-9.


Co-infection with HIV and HCV is associated with accelerated progression of liver disease and increased complications compared with HCV infection alone. Treatment of HCV and achievement of a sustained virologic response (SVR) can improve outcomes in these patients. Even after clearance of the hepatitis C virus, however, patients remain at risk, albeit diminished, for the complications of chronic liver disease. As such, longitudinal monitoring of treated patients remains important for clinicians caring for this population. This article summarizes the benefits and persistent risks after attaining SVR. It reviews the natural history of fibrosis and addresses the monitoring and management of progressive liver disease.

Publication types

  • Review

MeSH terms

  • Antiviral Agents / therapeutic use*
  • Carcinoma, Hepatocellular / etiology
  • Carcinoma, Hepatocellular / prevention & control
  • Coinfection / drug therapy*
  • Coinfection / virology
  • Disease Management
  • Drug Therapy, Combination
  • HIV Infections / complications
  • HIV Infections / drug therapy*
  • HIV Infections / virology
  • Hepatitis C, Chronic / complications
  • Hepatitis C, Chronic / drug therapy*
  • Hepatitis C, Chronic / virology
  • Humans
  • Liver Cirrhosis / etiology
  • Liver Cirrhosis / prevention & control*
  • Liver Neoplasms / etiology
  • Liver Neoplasms / prevention & control
  • Practice Guidelines as Topic


  • Antiviral Agents