Marker-based mapping of quantitative trait loci using replicated progenies

Theor Appl Genet. 1990 Aug;80(2):205-8. doi: 10.1007/BF00224388.


When heritability of the trait under investigation is low, replicated progenies can bring about a major reduction in the number of individuals that need to be scored for marker genotype in determining linkage between marker loci and quantitative trait loci (QTL). Savings are greatest when heritability of the trait is low, but are much reduced when heritability of the quantitative trait is moderate to high. Required numbers for recombinant inbred lines will be greater than those required for a simple F2 population when heritabilities are moderate to high and the proportion of recombination between marker locus and quantitative trait locus is substantial.