PSAR-align: improving multiple sequence alignment using probabilistic sampling

Bioinformatics. 2014 Apr 1;30(7):1010-2. doi: 10.1093/bioinformatics/btt636. Epub 2013 Nov 12.


Summary: We developed PSAR-Align, a multiple sequence realignment tool that can refine a given multiple sequence alignment based on suboptimal alignments generated by probabilistic sampling. Our evaluation demonstrated that PSAR-Align is able to improve the results from various multiple sequence alignment tools.

Availability and implementation: The PSAR-Align source code (implemented mainly in C++) is freely available for download at

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • High-Throughput Nucleotide Sequencing / methods*
  • Probability
  • Sequence Alignment
  • Software*