Inhibitory effects of sweet cherry anthocyanins on the obesity development in C57BL/6 mice

Int J Food Sci Nutr. 2014 May;65(3):351-9. doi: 10.3109/09637486.2013.854749. Epub 2013 Nov 13.

Abstract

In the present study, purified sweet cherry anthocyanins (CACN) were evaluated to determine their inhibitory effects on adipocyte differentiation of 3T3-L1 cells and their anti-obesity properties in male C57BL/6 mice fed with high-fat diet (HFD). CACN prevented HFD-induced obesity in C57BL/6 mice. In vivo experiment revealed that 40 and 200 mg/kg of CACN in food reduced the body weight by 5.2% and 11.2%, respectively. CACN supplementation could also reduce the size of adipocytes, leptin secretion, serum glucose, triglyceride, total cholesterol, LDL-cholesterol and liver triglycerides. Furthermore, CACN could effectively reduce the expression levels of IL-6 and TNFα genes, markedly increase the SOD and GPx activity. Our results indicated that CACN slowed down the development of HFD-induced obesity in male C57BL/6 mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3-L1 Cells
  • Adipocytes / drug effects
  • Adipogenesis / drug effects*
  • Adipose Tissue / cytology
  • Adipose Tissue / drug effects*
  • Animals
  • Anthocyanins / pharmacology
  • Anthocyanins / therapeutic use*
  • Anti-Obesity Agents
  • Blood Glucose / metabolism
  • Diet, High-Fat
  • Dietary Supplements*
  • Interleukin-6 / genetics
  • Interleukin-6 / metabolism
  • Leptin / metabolism
  • Lipid Metabolism / drug effects
  • Liver / drug effects
  • Liver / metabolism
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Obesity / blood
  • Obesity / etiology
  • Obesity / metabolism
  • Obesity / prevention & control*
  • Phytotherapy
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Prunus / chemistry*
  • Tumor Necrosis Factor-alpha / genetics
  • Tumor Necrosis Factor-alpha / metabolism
  • Weight Loss / drug effects*

Substances

  • Anthocyanins
  • Anti-Obesity Agents
  • Blood Glucose
  • Interleukin-6
  • Leptin
  • Plant Extracts
  • Tumor Necrosis Factor-alpha