Abstract
In the present study, purified sweet cherry anthocyanins (CACN) were evaluated to determine their inhibitory effects on adipocyte differentiation of 3T3-L1 cells and their anti-obesity properties in male C57BL/6 mice fed with high-fat diet (HFD). CACN prevented HFD-induced obesity in C57BL/6 mice. In vivo experiment revealed that 40 and 200 mg/kg of CACN in food reduced the body weight by 5.2% and 11.2%, respectively. CACN supplementation could also reduce the size of adipocytes, leptin secretion, serum glucose, triglyceride, total cholesterol, LDL-cholesterol and liver triglycerides. Furthermore, CACN could effectively reduce the expression levels of IL-6 and TNFα genes, markedly increase the SOD and GPx activity. Our results indicated that CACN slowed down the development of HFD-induced obesity in male C57BL/6 mice.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3T3-L1 Cells
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Adipocytes / drug effects
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Adipogenesis / drug effects*
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Adipose Tissue / cytology
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Adipose Tissue / drug effects*
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Animals
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Anthocyanins / pharmacology
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Anthocyanins / therapeutic use*
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Anti-Obesity Agents
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Blood Glucose / metabolism
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Diet, High-Fat
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Dietary Supplements*
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Interleukin-6 / genetics
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Interleukin-6 / metabolism
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Leptin / metabolism
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Lipid Metabolism / drug effects
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Liver / drug effects
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Liver / metabolism
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Male
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Mice
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Mice, Inbred C57BL
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Obesity / blood
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Obesity / etiology
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Obesity / metabolism
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Obesity / prevention & control*
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Phytotherapy
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use
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Prunus / chemistry*
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Tumor Necrosis Factor-alpha / genetics
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Tumor Necrosis Factor-alpha / metabolism
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Weight Loss / drug effects*
Substances
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Anthocyanins
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Anti-Obesity Agents
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Blood Glucose
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Interleukin-6
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Leptin
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Plant Extracts
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Tumor Necrosis Factor-alpha