Effect of antipsychotic and other classes of drugs on spontaneous locomotor activity and neurotoxicity in mice

Pharmacol Biochem Behav. 1978 Jan;8(1):97-9. doi: 10.1016/0091-3057(78)90130-2.


Quantitative estimates were made of the effects of several classes of drugs on spontaneous activity and neurotoxicity in mice. Clinically effective antipsychotic agents had a more selective action on spontaneous activity than other classes of drugs with the exception of clonidine and a related compound.

MeSH terms

  • Animals
  • Antipsychotic Agents / pharmacology*
  • Antipsychotic Agents / toxicity
  • Brain / drug effects*
  • Dose-Response Relationship, Drug
  • Male
  • Mice
  • Motor Activity / drug effects*


  • Antipsychotic Agents