Piecing together the puzzle of severe malaria

Sci Transl Med. 2013 Nov 13;5(211):211ps18. doi: 10.1126/scitranslmed.3007432.


Severe malaria manifests as several overlapping syndromes with high mortality. Interaction of parasites with endothelial protein C receptors and high parasite biomass have recently been identified as key determinants of severe disease. However, gaps in our understanding of severe malaria might hinder translation of these findings into new therapies.

MeSH terms

  • Host-Parasite Interactions
  • Humans
  • Malaria / immunology
  • Malaria / parasitology
  • Malaria / physiopathology*
  • Plasmodium / classification
  • Plasmodium / immunology
  • Severity of Illness Index