Site selection and pain outcome after autologous bone graft harvest

Foot Ankle Int. 2014 Feb;35(2):104-7. doi: 10.1177/1071100713511434. Epub 2013 Nov 13.


Background: In foot and ankle surgery, there are multiple sites used for autologous bone graft, including the proximal (PT) or distal tibia (DT), calcaneus (C), and iliac crest (ICBG). There has been no comparison between these anatomic areas and the potential for acute or persistent pain at 1 year. The purpose of this study was to prospectively compare patient-reported outcomes of acute and persistent pain at 1 year after surgery to determine if harvest site selection made a difference.

Methods: As part of a clinical trial examining ankle and hindfoot fusion rates with autograft compared with synthetic graft, the autologous bone graft harvest sites were assessed with visual analog pain outcome scores at 3, 24, 36, and 52 weeks after surgery. Patients with a score of 20+ defined clinically significant pain. Four harvest sites were compared: ICBG, PT, DT, and C. Fisher exact test was used to compare the graft site pain between locations.

Results: Twelve percent of subjects reported clinically significant pain at 24 weeks and 8.5% at 52 weeks postoperatively. Each lower extremity harvest site (C, DT, PT) showed higher rates of clinically significant graft harvest site pain than the ICBG at 52 weeks.

Conclusions: Autologous bone graft harvest carried a risk of persistent pain at up to 1 year (weeks 24-52) in 18% of patients. Lower-extremity bone graft sites had the greatest risk for persistent pain at 1 year.

Level of evidence: Level II, prospective comparative study.

Keywords: bone graft pain; foot and ankle autologous graft.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bone Transplantation / adverse effects
  • Bone Transplantation / methods*
  • Calcaneus / transplantation*
  • Canada
  • Humans
  • Ilium / transplantation*
  • Pain Measurement
  • Pain, Postoperative*
  • Prospective Studies
  • Tibia / transplantation*
  • Tissue and Organ Harvesting*
  • Transplantation, Autologous
  • Treatment Outcome
  • United States