Salivary visfatin concentrations in patients with chronic periodontitis

J Periodontol. 2014 Aug;85(8):1081-5. doi: 10.1902/jop.2013.130388. Epub 2013 Nov 14.


Background: Visfatin, also known as pre-B-cell colony-enhancing factor, is secreted from a variety of cells and is thought to have some proinflammatory and immunomodulating effects. It is indicated that serum/plasma levels of visfatin increase in a number of inflammatory disorders. The present study aims to evaluate salivary concentrations of visfatin in patients with chronic periodontitis (CP).

Methods: Twenty patients with CP and 20 periodontally healthy individuals were enrolled in this study. For each patient, the values of clinical parameters, such as bleeding index, plaque index, probing depth, and clinical attachment level (CAL), were recorded. Whole saliva samples were collected, and concentrations of visfatin were evaluated using standard enzyme-linked immunosorbent assay. Statistical analysis was performed using statistical software.

Results: Visfatin was detectable in all samples. Salivary visfatin concentrations were significantly higher in the periodontitis group. In addition, there was a positive significant relationship between salivary visfatin concentrations and CAL in the periodontitis group. However, no significant association was observed between salivary visfatin levels and other periodontal parameters or body mass index.

Conclusion: These results indicate that there is a relationship between salivary visfatin and CP; however, further studies are needed to confirm this finding.

Keywords: Adipokines; chronic periodontitis; nicotinamide phosphoribosyltransferase; saliva.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / analysis
  • Body Mass Index
  • Case-Control Studies
  • Chronic Periodontitis / metabolism*
  • Cross-Sectional Studies
  • Cytokines / analysis*
  • Dental Plaque Index
  • Female
  • Humans
  • Immunologic Factors / analysis
  • Inflammation Mediators / analysis
  • Male
  • Middle Aged
  • Nicotinamide Phosphoribosyltransferase / analysis*
  • Periodontal Attachment Loss / classification
  • Periodontal Attachment Loss / metabolism
  • Periodontal Index
  • Periodontal Pocket / classification
  • Periodontal Pocket / metabolism
  • Saliva / chemistry*
  • Salivary Proteins and Peptides / analysis*
  • Young Adult


  • Biomarkers
  • Cytokines
  • Immunologic Factors
  • Inflammation Mediators
  • Salivary Proteins and Peptides
  • Nicotinamide Phosphoribosyltransferase
  • nicotinamide phosphoribosyltransferase, human