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Review
. 2013 Aug;78(8):855-66.
doi: 10.1134/S0006297913080014.

Protein Biosynthesis in Mitochondria

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Free PMC article
Review

Protein Biosynthesis in Mitochondria

A V Kuzmenko et al. Biochemistry (Mosc). .
Free PMC article

Abstract

Translation, that is biosynthesis of polypeptides in accordance with information encoded in the genome, is one of the most important processes in the living cell, and it has been in the spotlight of international research for many years. The mechanisms of protein biosynthesis in bacteria and in the eukaryotic cytoplasm are now understood in great detail. However, significantly less is known about translation in eukaryotic mitochondria, which is characterized by a number of unusual features. In this review, we summarize current knowledge about mitochondrial translation in different organisms while paying special attention to the aspects of this process that differ from cytoplasmic protein biosynthesis.

Figures

Fig. 1
Fig. 1. Schematic representation of translation initiation in mitochondria.
SRS, small ribosomal subunit; LRS, large ribosomal subunit. See text for details.
Fig. 2
Fig. 2. Schematic representation of translation elongation in mitochondria.
SRS, small ribosomal subunit; LRS, large ribosomal subunit. See text for detailed information.
Fig. 3
Fig. 3. Schematic representation of translation termination in mitochondria.
SRS, small ribosomal subunit; LRS, large ribosomal subunit. See text for details.

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