Significance of CD66c expression in childhood acute lymphoblastic leukemia

Leuk Res. 2014 Jan;38(1):42-8. doi: 10.1016/j.leukres.2013.10.008. Epub 2013 Oct 22.


Upon analyzing 696 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases, we identified the characteristics of CD66c expression. In addition to the confirmation of strong correlation with BCR-ABL positivity and hyperdiploid, we further observed that CD66c is frequently expressed in CRLF2-positive (11/15, p<0.01 against chimeric gene-negative) as well as hypodiploid cases (3/4), whereas it is never expressed in ETV6-RUNX1, MLL-AF4, MLL-AF9, MLL-ENL, and E2A-PBX1-positive cases. Although the expression of CD66c itself is not directly linked to the prognosis, the accompanying genetic abnormalities are important prognostic factors for BCP-ALL, indicating the importance of CD66c expression in the initial diagnosis of BCP-ALL.

Keywords: Acute lymphoblastic leukemia; CD66c; CRLF2, Flow cytometry; Genetic abnormality.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antigens, CD / metabolism*
  • Cell Adhesion Molecules / metabolism*
  • Child
  • Child, Preschool
  • Core Binding Factor Alpha 2 Subunit / genetics
  • Female
  • Flow Cytometry
  • Fusion Proteins, bcr-abl / genetics
  • GPI-Linked Proteins / metabolism
  • Gene Expression Regulation, Neoplastic
  • Homeodomain Proteins / genetics
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Myeloid-Lymphoid Leukemia Protein / genetics
  • Oncogene Proteins, Fusion / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Prognosis
  • Receptors, Cytokine / metabolism*
  • Reverse Transcriptase Polymerase Chain Reaction


  • Antigens, CD
  • CEACAM6 protein, human
  • CRLF2 protein, human
  • Cell Adhesion Molecules
  • Core Binding Factor Alpha 2 Subunit
  • GPI-Linked Proteins
  • Homeodomain Proteins
  • MLL-AF4 fusion protein, human
  • MLL-AF9 fusion protein, human
  • MLL-ENL oncoprotein, human
  • Oncogene Proteins, Fusion
  • Receptors, Cytokine
  • TEL-AML1 fusion protein
  • E2A-Pbx1 fusion protein
  • Myeloid-Lymphoid Leukemia Protein
  • Fusion Proteins, bcr-abl