The regionalization of [3H]dihydrotetrabenazine binding sites in the mouse brain and its relationship to the distribution of monoamines and their metabolites

Brain Res. 1986 Apr 2;370(1):176-81. doi: 10.1016/0006-8993(86)91120-0.

Abstract

[3H]Dihydrotetrabenazine binding was measured in 8 areas of the mouse brain. In all areas, binding occurred on a homogeneous class of sites (Kd approximately equal to 2.6 nM). The density of [3H]dihydrotetrabenazine binding sites strongly varied between the different brain structures; it was compared to endogenous levels of biogenic monoamines and their metabolites: the density is independent of the nature of the monoamine and of neuronal activity, but is highly correlated to the total amount of monoamines present in each structure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3,4-Dihydroxyphenylacetic Acid / analysis
  • Animals
  • Binding Sites
  • Biogenic Amines / analysis*
  • Brain / metabolism*
  • Homovanillic Acid / analysis
  • Hydroxyindoleacetic Acid / analysis
  • Male
  • Mice
  • Nerve Tissue Proteins / analysis
  • Serotonin / analysis
  • Synaptic Vesicles / metabolism
  • Tetrabenazine / analogs & derivatives*
  • Tetrabenazine / metabolism

Substances

  • Biogenic Amines
  • Nerve Tissue Proteins
  • 3,4-Dihydroxyphenylacetic Acid
  • Serotonin
  • dihydrotetrabenazine
  • Hydroxyindoleacetic Acid
  • Homovanillic Acid
  • Tetrabenazine