Abstract
[3H]Dihydrotetrabenazine binding was measured in 8 areas of the mouse brain. In all areas, binding occurred on a homogeneous class of sites (Kd approximately equal to 2.6 nM). The density of [3H]dihydrotetrabenazine binding sites strongly varied between the different brain structures; it was compared to endogenous levels of biogenic monoamines and their metabolites: the density is independent of the nature of the monoamine and of neuronal activity, but is highly correlated to the total amount of monoamines present in each structure.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3,4-Dihydroxyphenylacetic Acid / analysis
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Animals
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Binding Sites
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Biogenic Amines / analysis*
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Brain / metabolism*
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Homovanillic Acid / analysis
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Hydroxyindoleacetic Acid / analysis
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Male
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Mice
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Nerve Tissue Proteins / analysis
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Serotonin / analysis
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Synaptic Vesicles / metabolism
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Tetrabenazine / analogs & derivatives*
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Tetrabenazine / metabolism
Substances
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Biogenic Amines
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Nerve Tissue Proteins
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3,4-Dihydroxyphenylacetic Acid
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Serotonin
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dihydrotetrabenazine
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Hydroxyindoleacetic Acid
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Homovanillic Acid
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Tetrabenazine