Chronic posttraumatic cartilage lesion of the knee treated with an acellular osteochondral-regenerating implant: case history with rehabilitation guidelines

J Sport Rehabil. 2014 Aug;23(3):270-5. doi: 10.1123/jsr.2013-0054. Epub 2013 Nov 14.


Osteochondral defects are often symptomatic and lead to deranged joint function. The spontaneous healing capacity of osteochondral defects is limited. In this case study, use of an acellular scaffold capable of induction of mesenchymal stem-cell migration is described. This scaffold was used on an Outerbridge grade IV medical condylar defect measuring ~2 cm2. At 24 mo follow-up, the articular surface appeared restored by MRI, and the patient returned to sports.

Publication types

  • Case Reports

MeSH terms

  • Cartilage, Articular / diagnostic imaging
  • Cartilage, Articular / injuries
  • Cartilage, Articular / surgery*
  • Chronic Pain
  • Humans
  • Knee Injuries / rehabilitation*
  • Male
  • Mesenchymal Stem Cells / metabolism
  • Middle Aged
  • Radiography
  • Tissue Scaffolds*