Location of 'continuous' antigenic determinants in the protruding regions of proteins

EMBO J. 1986 Feb;5(2):409-13. doi: 10.1002/j.1460-2075.1986.tb04226.x.


A simple method is described to locate 'antigenic' peptides from the alpha-carbon co-ordinates of a protein, based on protrusion from the protein's globular surface. A good correlation is found between those parts of a protein which protrude and the experimentally determined antigenic peptides in myoglobin, lysozyme and myohemerythrin. A comparison is made between the use of protrusion index, mobility, solvent accessibility and hydrophilicity for predicting the most likely antigenic peptides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Epitopes / analysis*
  • Hemerythrin / analogs & derivatives
  • Hemerythrin / immunology
  • Models, Molecular
  • Muramidase / immunology
  • Myoglobin / immunology
  • Pigments, Biological / immunology
  • Protein Conformation
  • Proteins / immunology*
  • Surface Properties


  • Epitopes
  • Hemerythrin
  • Myoglobin
  • Pigments, Biological
  • Proteins
  • myohemerythrin
  • Muramidase