Abstract
Columnar epithelial cells (EC), isolated from the proximal small intestine of the rat, bind ovalbumin (OVA) by a non-specific, cold-inhibitable mechanism and continue to express Ia antigens after 24 hr culture in vitro. Lymph node T cells from rats immunized with OVA proliferate following 18 hr coculture with EC and OVA. This accessory cell function of EC is antigen-specific and is blocked by anti-Ia monoclonal antisera.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigen-Presenting Cells / immunology*
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Epithelium / immunology
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Epitopes / immunology*
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Histocompatibility Antigens Class II / immunology*
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Immune Sera / immunology
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Intestinal Mucosa / immunology*
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Intestine, Small / immunology*
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Kinetics
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Lymphocyte Activation
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Male
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Rats
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Rats, Inbred WF
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T-Lymphocytes / immunology
Substances
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Epitopes
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Histocompatibility Antigens Class II
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Immune Sera