Antigen presentation by epithelial cells of the rat small intestine. I. Kinetics, antigen specificity and blocking by anti-Ia antisera

Immunology. 1986 May;58(1):1-7.

Abstract

Columnar epithelial cells (EC), isolated from the proximal small intestine of the rat, bind ovalbumin (OVA) by a non-specific, cold-inhibitable mechanism and continue to express Ia antigens after 24 hr culture in vitro. Lymph node T cells from rats immunized with OVA proliferate following 18 hr coculture with EC and OVA. This accessory cell function of EC is antigen-specific and is blocked by anti-Ia monoclonal antisera.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigen-Presenting Cells / immunology*
  • Epithelium / immunology
  • Epitopes / immunology*
  • Histocompatibility Antigens Class II / immunology*
  • Immune Sera / immunology
  • Intestinal Mucosa / immunology*
  • Intestine, Small / immunology*
  • Kinetics
  • Lymphocyte Activation
  • Male
  • Rats
  • Rats, Inbred WF
  • T-Lymphocytes / immunology

Substances

  • Epitopes
  • Histocompatibility Antigens Class II
  • Immune Sera