A new twist to the GATA switch

Blood. 2013 Nov 14;122(20):3391-2. doi: 10.1182/blood-2013-09-527606.

Abstract

In this issue of Blood, Takai et al provide some tantalizing clues on how expression of the GATA1 transcription factor, a master regulator of erythroid/megakaryocytic differentiation, is suppressed in the hematopoietic stem/progenitor cell (HSPC) compartment.

Publication types

  • Comment

MeSH terms

  • Animals
  • Erythroid Cells / metabolism*
  • GATA1 Transcription Factor / genetics*
  • Gene Expression Regulation, Developmental / genetics*
  • Hematopoietic Stem Cells / metabolism*
  • Regulatory Sequences, Nucleic Acid / genetics*

Substances

  • GATA1 Transcription Factor
  • Gata1 protein, mouse