Antiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 3

Int J Nanomedicine. 2013:8:4303-14. doi: 10.2147/IJN.S50070. Epub 2013 Nov 6.


The interaction between silver nanoparticles and viruses is attracting great interest due to the potential antiviral activity of these particles, and is the subject of much research effort in the treatment of infectious diseases. In this work, we demonstrate that silver nanoparticles undergo a size-dependent interaction with herpes simplex virus types 1 and 2 and with human parainfluenza virus type 3. We show that production of silver nanoparticles from different fungi is feasible, and their antiviral activity is dependent on the production system used. Silver nanoparticles are capable of reducing viral infectivity, probably by blocking interaction of the virus with the cell, which might depend on the size and zeta potential of the silver nanoparticles. Smaller-sized nanoparticles were able to inhibit the infectivity of the viruses analyzed.

Keywords: antiviral; herpes simplex virus; parainfluenza virus; silver nanoparticles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Fungi / isolation & purification
  • Fungi / metabolism*
  • Metal Nanoparticles / chemistry*
  • Parainfluenza Virus 3, Human / drug effects*
  • Plants / microbiology
  • Silver / chemistry
  • Silver / pharmacology*
  • Simplexvirus / drug effects*
  • Vero Cells


  • Antiviral Agents
  • Silver