Hematologic manifestations of systemic disease (including iron deficiency, anemia of inflammation and DIC)

Pediatr Clin North Am. 2013 Dec;60(6):1337-48. doi: 10.1016/j.pcl.2013.08.012. Epub 2013 Oct 4.


A complete blood cell count (CBC) is a frequent test sent to aid in the diagnostic evaluation of ill patients. Not uncommonly hematologic abnormalities may be the first sign of an underlying systemic disorder. The astute clinician needs to understand how systemic disease can affect the CBC to direct further diagnostic investigations. This article focuses on the 2 most common acquired anemias including iron deficiency and anemia of inflammation as well as disseminated intravascular coagulation.

Keywords: Anemia of inflammation; Disseminated intravascular coagulation; Function of hemoglobin; Iron deficiency anemia.

Publication types

  • Review

MeSH terms

  • Anemia / diagnosis*
  • Anemia / drug therapy
  • Anemia, Iron-Deficiency / blood
  • Anemia, Iron-Deficiency / diagnosis*
  • Anemia, Iron-Deficiency / drug therapy
  • Blood Cell Count
  • Disseminated Intravascular Coagulation / diagnosis*
  • Disseminated Intravascular Coagulation / drug therapy
  • Humans
  • Inflammation