Scedosporium aurantiacum brain abscess after near-drowning in a survivor of a tsunami in Japan

Respir Investig. 2013 Dec;51(4):207-11. doi: 10.1016/j.resinv.2013.07.001. Epub 2013 Aug 20.

Abstract

Many victims of the tsunami that occurred following the Great East Japan Earthquake on March 11, 2011 developed systemic disorders owing to aspiration pneumonia. Herein, we report a case of tsunami lung wherein Scedosporium aurantiacum was detected in the respiratory tract. A magnetic resonance image of the patient's head confirmed multiple brain abscesses and lateral right ventricle enlargement. In this case report, we describe a potential refractory multidrug-resistant infection following a tsunami disaster.

Keywords: BAL; CNS; CSF; CT; F; FLC; L-AMB; M; MCFG; MRI; Near-drowning; PCR; PMX-DHP; Scedosporium apiospermum; Scedosporium aurantiacum; Scedosporium prolificans; Tsunami lung; VRCZ; bronchoalveolar lavage; central nervous system; cerebrospinal fluid; computed tomography; female; fluconazole; liposomal amphotericin B; magnetic resonance imaging; male; micafungin; polymerase chain reaction; polymyxin B-immobilized fiber column direct hemoperfusion; voriconazole.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aged
  • Amphotericin B / administration & dosage
  • Antifungal Agents / administration & dosage
  • Brain Abscess / diagnosis*
  • Brain Abscess / drug therapy
  • Brain Abscess / etiology*
  • Brain Abscess / therapy
  • Central Nervous System Fungal Infections / diagnosis
  • Central Nervous System Fungal Infections / drug therapy
  • Central Nervous System Fungal Infections / etiology*
  • Delayed Diagnosis*
  • Female
  • Humans
  • Japan
  • Lung Diseases, Fungal / diagnosis
  • Lung Diseases, Fungal / etiology
  • Lung Diseases, Fungal / therapy
  • Magnetic Resonance Imaging
  • Near Drowning / complications*
  • Pyrimidines / administration & dosage
  • Scedosporium* / isolation & purification
  • Survivors*
  • Tomography, X-Ray Computed
  • Triazoles / administration & dosage
  • Tsunamis*
  • Voriconazole

Substances

  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Amphotericin B
  • Voriconazole