Functional connectomics from resting-state fMRI

Trends Cogn Sci. 2013 Dec;17(12):666-82. doi: 10.1016/j.tics.2013.09.016. Epub 2013 Nov 12.

Abstract

Spontaneous fluctuations in activity in different parts of the brain can be used to study functional brain networks. We review the use of resting-state functional MRI (rfMRI) for the purpose of mapping the macroscopic functional connectome. After describing MRI acquisition and image-processing methods commonly used to generate data in a form amenable to connectomics network analysis, we discuss different approaches for estimating network structure from that data. Finally, we describe new possibilities resulting from the high-quality rfMRI data being generated by the Human Connectome Project and highlight some upcoming challenges in functional connectomics.

Keywords: connectomics; network modelling; resting-state fMRI.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / blood supply*
  • Brain / physiology*
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging*
  • Nerve Net / blood supply
  • Nerve Net / physiology
  • Neural Pathways / blood supply*
  • Oxygen / blood
  • Rest*

Substances

  • Oxygen