Gene expression profile based classification models of psoriasis

Genomics. 2014 Jan;103(1):48-55. doi: 10.1016/j.ygeno.2013.11.001. Epub 2013 Nov 13.

Abstract

Psoriasis is an autoimmune disease, which symptoms can significantly impair the patient's life quality. It is mainly diagnosed through the visual inspection of the lesion skin by experienced dermatologists. Currently no cure for psoriasis is available due to limited knowledge about its pathogenesis and development mechanisms. Previous studies have profiled hundreds of differentially expressed genes related to psoriasis, however with no robust psoriasis prediction model available. This study integrated the knowledge of three feature selection algorithms that revealed 21 features belonging to 18 genes as candidate markers. The final psoriasis classification model was established using the novel Incremental Feature Selection algorithm that utilizes only 3 features from 2 unique genes, IGFL1 and C10orf99. This model has demonstrated highly stable prediction accuracy (averaged at 99.81%) over three independent validation strategies. The two marker genes, IGFL1 and C10orf99, were revealed as the upstream components of growth signal transduction pathway of psoriatic pathogenesis.

Keywords: Classification; Gene expression profiles; Psoriasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Artificial Intelligence
  • Case-Control Studies
  • Cell Proliferation
  • Databases, Factual
  • Gene Expression Profiling
  • Genetic Markers
  • Humans
  • Microarray Analysis
  • Models, Genetic*
  • Psoriasis / classification
  • Psoriasis / diagnosis*
  • Psoriasis / genetics*
  • ROC Curve
  • Signal Transduction / genetics
  • Skin / cytology
  • Skin / pathology
  • Transcriptome*

Substances

  • Genetic Markers