Deciphering laminar-specific neural inputs with line-scanning fMRI

Nat Methods. 2014 Jan;11(1):55-8. doi: 10.1038/nmeth.2730. Epub 2013 Nov 17.

Abstract

Using a line-scanning method during functional magnetic resonance imaging (fMRI), we obtained high temporal (50-ms) and spatial (50-μm) resolution information along the cortical thickness and showed that the laminar position of fMRI onset coincides with distinct neural inputs in rat somatosensory and motor cortices. This laminar-specific fMRI onset allowed us to identify the neural inputs underlying ipsilateral fMRI activation in the barrel cortex due to peripheral denervation-induced plasticity.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Algorithms
  • Animals
  • Brain Mapping / methods
  • Cerebral Cortex / pathology
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging / methods*
  • Male
  • Manganese / chemistry
  • Motor Cortex / pathology*
  • Neuronal Plasticity / physiology*
  • Neurons / metabolism*
  • Neurons / pathology
  • Optics and Photonics
  • Rats
  • Rats, Sprague-Dawley
  • Time Factors

Substances

  • Manganese