Cardiac arrhythmias and conduction defects in systemic sclerosis

Rheumatology (Oxford). 2014 Jul;53(7):1172-7. doi: 10.1093/rheumatology/ket377. Epub 2013 Nov 15.


Signs and symptoms of arrhythmias or conduction defects are frequently reported in patients with SSc. These rhythm disorders may have several origins (i.e., related to primary heart involvement, pericardial disease, valvular regurgitation or pulmonary arterial hypertension) and may negatively affect the overall prognosis of these patients. It is therefore important to identify patients at high risk for cardiac arrhythmias with a complete cardiological evaluation and to identify the underlying heart disease, including SSc-related myocardial involvement. In addition, some therapeutic options in SSc patients may differ from those recommended in other populations.

Keywords: arrhythmias; cardiac involvement; conduction defects; mortality; systemic sclerosis.

Publication types

  • Review

MeSH terms

  • Anti-Arrhythmia Agents / therapeutic use
  • Arrhythmias, Cardiac / drug therapy
  • Arrhythmias, Cardiac / epidemiology*
  • Arrhythmias, Cardiac / physiopathology
  • Electrocardiography
  • Heart Conduction System / physiopathology*
  • Humans
  • Prognosis
  • Risk Factors
  • Scleroderma, Systemic / diagnosis
  • Scleroderma, Systemic / physiopathology*


  • Anti-Arrhythmia Agents