Bifidobacterium bifidum PRL2010 modulates the host innate immune response

Appl Environ Microbiol. 2014 Jan;80(2):730-40. doi: 10.1128/AEM.03313-13. Epub 2013 Nov 15.


Here, we describe data obtained from transcriptome profiling of human cell lines and intestinal cells of a murine model upon exposure and colonization, respectively, with Bifidobacterium bifidum PRL2010. Significant changes were detected in the transcription of genes that are known to be involved in innate immunity. Furthermore, results from enzyme-linked immunosorbent assays (ELISAs) showed that exposure to B. bifidum PRL2010 causes enhanced production of interleukin 6 (IL-6) and IL-8 cytokines, presumably through NF-κB activation. The obtained global transcription profiles strongly suggest that Bifidobacterium bifidum PRL2010 modulates the innate immune response of the host.

MeSH terms

  • Animals
  • Bifidobacterium / physiology*
  • Caco-2 Cells / microbiology
  • Cell Line
  • Cytokines / genetics
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Gene Expression Profiling
  • HT29 Cells / drug effects
  • HT29 Cells / microbiology
  • Humans
  • Immunity, Innate* / genetics
  • Interleukin-8 / metabolism
  • Intestines / cytology
  • Intestines / immunology*
  • Intestines / microbiology*
  • Mice
  • Mice, Inbred BALB C
  • NF-kappa B / metabolism
  • Probiotics / pharmacology*


  • Cytokines
  • Interleukin-8
  • NF-kappa B

Associated data

  • GEO/GSE48533