Stochastic fate selection in HIV-infected patients

Cell. 2013 Oct 24;155(3):497-9. doi: 10.1016/j.cell.2013.09.039. Epub 2013 Oct 24.


Classic studies proposed that stochastic variability ("noise") can drive biological fate switching, enhancing evolutionary success. Now, Ho et al. report that HIV's reactivation from dormant (latently infected) patient cells-the major barrier to an HIV cure-is inherently stochastic. Eradicating an incompletely inducible (probabilistic) viral phenotype will require inventive approaches.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • HIV Infections / drug therapy*
  • HIV Infections / virology*
  • HIV-1 / genetics*
  • Virus Latency*