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. 2014 Apr;36(2):665-76.
doi: 10.1007/s11357-013-9596-x. Epub 2013 Nov 16.

Exercise-training-induced changes in metabolic capacity with age: the role of central cardiovascular plasticity

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Exercise-training-induced changes in metabolic capacity with age: the role of central cardiovascular plasticity

Eivind Wang et al. Age (Dordr). 2014 Apr.

Abstract

Although aging is typically associated with a decline in maximal oxygen consumption (VO2max), young and old subjects, of similar initial muscle metabolic capacity, increased quadriceps VO2max equally when this small muscle mass was trained in isolation. As it is unclear if this preserved exercise-induced plasticity with age is still evident with centrally challenging whole body exercise, we assessed maximal exercise responses in 13 young (24 ± 2 years) and 13 old (60 ± 3 years) males, matched for cycling VO2max (3.82 ± 0.66 and 3.69 ± 0.30 L min(-1), respectively), both before and after 8 weeks of high aerobic intensity cycle exercise training. As a consequence of the training both young and old significantly improved VO2max (13 ± 6 vs. 6 ± 7 %) and maximal power output (20 ± 6 vs. 10 ± 6 %, respectively) from baseline, however, the young exhibited a significantly larger increase than the old. Similarly, independently assessed maximal cardiac output (Q max) tended to increase more in the young (16 ± 14 %) than in the old (11 ± 12 %), with no change in a-vO2 difference in either group. Further examination of the components of Q max provided additional evidence of reduced exercise-induced plasticity in both maximal heart rate (young -3 %, old 0 %) and stroke volume (young 19 ± 15, old 11 ± 11 %) in the old. In combination, these findings imply that limited central cardiovascular plasticity may be responsible, at least in part, for the attenuated response to whole body exercise training with increasing age.

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Figures

Fig. 1
Fig. 1
Maximal oxygen consumption (VO2max) from pre- to post-high aerobic intensity exercise training in young and old subjects. Data are presented as mean ± SE. #Significant difference (p < 0.01) within group from pre- to post-test. *Significant difference (p < 0.01) between groups from pre- to post-test
Fig. 2
Fig. 2
Maximal cardiac output (a), maximal heart rate (b), and maximal stroke volume (c) from pre- to post-high aerobic intensity exercise training in young and old subjects. Data are presented as mean ± SE. §Significant difference between groups at baseline. #Significant difference (p < 0.01) within group from pre- to post-test. *Significant difference (p < 0.01) between groups from pre- to post-test

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