Colorectal carcinoma infiltration by myeloperoxidase-expressing neutrophil granulocytes is associated with favorable prognosis

Oncoimmunology. 2013 Oct 1;2(10):e25990. doi: 10.4161/onci.25990. Epub 2013 Sep 12.


The prognostic relevance of innate immune cells infiltrating colorectal carcinoma lesions is highly debated. By evaluating the expression of myeloperoxidase (MPO) as a marker of neutrophil granulocytes in a large cohort of colorectal carcinoma specimens, we have observed that robust tumor-infiltration by MPO+ cells correlates with improved patient survival independently of other histopathological parameters, including disease stage.

Keywords: CD15; human colorectal cancer; mismatch repair status; myeloperoxidase; prognosis; tissue microarray.