Glial fibrillary acidic protein and vimentin in the experimental glial reaction of the rat brain

Brain Res. 1986 May 21;374(1):110-8. doi: 10.1016/0006-8993(86)90399-9.


Glial reaction has been studied in the rat by the immunohistochemical demonstration of glial fibrillary acidic protein (GFAP) and vimentin (VIM) in two experimental conditions. The first was represented by a necrotic cerebral lesion obtained by laser irradiation and the second by the development of experimental tumors induced by transplacental ethylnitrosourea. Reactive astrocytes develop not only in the proximity of the lesion but also distant from it. The intensity of the glial response seems to depend upon the normal distribution of astrocytes and the perilesional edema. GFAP decorates all the reactive astrocytes, whereas VIM is positive only in those at the edges of the lesion. The significance of the different responses in the two models and between the two intermediate filaments is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Astrocytes / metabolism*
  • Astrocytes / pathology
  • Brain / metabolism*
  • Brain / pathology
  • Brain Neoplasms / chemically induced
  • Brain Neoplasms / metabolism
  • Brain Neoplasms / pathology
  • Disease Models, Animal
  • Ethylnitrosourea
  • Female
  • Glial Fibrillary Acidic Protein / analysis
  • Glial Fibrillary Acidic Protein / metabolism*
  • Lasers
  • Nerve Crush
  • Pregnancy
  • Rats
  • Rats, Inbred F344
  • Staining and Labeling
  • Vimentin / analysis
  • Vimentin / metabolism*


  • Glial Fibrillary Acidic Protein
  • Vimentin
  • Ethylnitrosourea