Rejuvenation effects of hyaluronic acid injection on nasojugal groove: prospective randomized split face clinical controlled study

J Cosmet Laser Ther. 2014 Jan;16(1):32-6. doi: 10.3109/14764172.2013.854620. Epub 2013 Nov 19.


Background: Pronounced nasojugal groove (tear trough deformity) is one of the landmarks of aging. Hyaluronic acid filler can be used for attenuating the nasojugal sulcus but irregular lumpness and overcorrection are common adverse reactions.

Objectives: We evaluated the effect of Restylane Vital® with its specialized injector on volume correction and skin tone of nasojugal groove.

Subjects and method: Ten Korean women were enrolled in this study. Subjects were randomized to be injected a stabilized hyaluronic acid-based gel of nonanimal origin (NAHSA injector, Restylane Vital®, Q-med) on one side of nasojugal groove, with the other side paired as control. The treatment was performed in one session. Outcome assessments included standardized photography, mexameter, and spectrometer for skin tone, global evaluation by blinded investigators, and patients' self-assessment. An assessment was made before treatment, immediately after treatment, and 1, 3, and 6 months after the treatment.

Results: All patients reported a high degree of satisfaction. Duration of overall effect varied among the patients. Correction of the nasojugal groove with a Restylane Vital® injector causes minimal tissue trauma and allows exact placement of hyaluronic acid. Restylane Vital® injector offers more predictable results and a lower incidence of adverse effects than more commonly used techniques.

Conclusions: Hyaluronic acid filler intradermal injection with special injector is a safe and effective method for correction of nasojugal groove.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Dermatologic Agents / administration & dosage*
  • Eye
  • Humans
  • Hyaluronic Acid / administration & dosage*
  • Injections / instrumentation
  • Middle Aged
  • Patient Satisfaction
  • Rejuvenation*
  • Single-Blind Method
  • Skin Aging*


  • Dermatologic Agents
  • Hyaluronic Acid