Metabolic and anti-inflammatory effects of a home-based programme of aerobic physical exercise

Int J Clin Pract. 2013 Dec;67(12):1247-53. doi: 10.1111/ijcp.12269.


Aims: Regular exercise demonstrated the ability to provide enormous benefits to many diseases, atherosclerotic-based, degenerative and neoplastic, but also to grant anti-inflammatory actions, assessed by various authors in different populations. Despite of these clear benefits, many patients are unable to attain long-term results through chronic physical activity for different causes. On this basis, the aim of our study was to assess the metabolic and anti-inflammatory effects of a home-based programme of fast walking in patients affected by metabolic syndrome (MS).

Materials and methods: We enrolled 176 subjects with MS as stated by ATP III criteria. Patients were invited to walk for 1 h every day 5 days a week for 24 weeks. The walking velocity was required higher than the one retained 'comfortable' by the patient, previously assessed in the run-in visit. Monitoring of physical activity was carried out through an OMRON step counter type Walking Style II. All the subjects enrolled completed the training period.

Results: After the 24 weeks of intervention body mass index changed from 31.59 to 29.23 (p < 0.001); mean waist circumference passed from 105.19 to 100.06 cm (p < 0.001); mean fasting glucose changed from 119.76 to 114.32 mg/dl (p < 0.001); for diabetic population (n = 70) mean glicated haemoglobin levels changed from 7.38% to 6.86% (p < 0.001); total cholesterol levels from 192.15 to 185.78 mg/dl (p < 0.001); HDL cholesterol levels raised from 44.03 to 47.63 mg/dl (p < 0.001); triglycerides levels lowered from 148.29 to 135.20 mg/dl (p < 0.001); WBC changed from 7361.08 to 7022.56/mm(3) (p < 0.001); hs-CRP from 0.55 to 0.28 mg/dl (p < 0.001); fibrinogen serum levels lowered from 339.68 to 314.86 mg/dl (p < 0.001).

Conclusions: A long-term home-based programme of aerobic physical activity improves metabolic asset and reduces systemic inflammation in sedentary people.

Publication types

  • Clinical Trial
  • Multicenter Study

MeSH terms

  • Body Mass Index
  • Cardiovascular Diseases / prevention & control
  • Energy Metabolism
  • Exercise / physiology
  • Exercise Therapy / methods*
  • Female
  • Home Care Services
  • Humans
  • Inflammation / prevention & control
  • Male
  • Metabolic Syndrome / therapy*
  • Middle Aged
  • Monitoring, Ambulatory
  • Risk Factors
  • Sedentary Behavior
  • Waist Circumference
  • Walking / physiology