Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 25 (4), 302-7

Apathy Is Associated With Increased Amyloid Burden in Mild Cognitive Impairment

Apathy Is Associated With Increased Amyloid Burden in Mild Cognitive Impairment

Gad A Marshall et al. J Neuropsychiatry Clin Neurosci.

Abstract

Apathy is the most common neuropsychiatric symptom in mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia. The authors sought to determine whether apathy is associated with cortical amyloid burden, as measured by Pittsburgh Compound B (PiB) positron emission tomography (PET), and regional hypometabolism, measured by 18F-fluorodeoxyglocuse (FDG) PET in MCI. The authors found a significant association between increased apathy (lower Apathy Evaluation Scale score) and greater cortical PiB retention independent of age, but no significant association between apathy and regional FDG metabolism. These results suggest that increased apathy is associated with greater amyloid burden but not regional hypometabolism in MCI.

Figures

Figure
Figure
Scatter plot of cortical PiB DVR vs. AES. Unadjusted Spearman’s correlation coefficient and p value are reported here, while the main analyses used partial Spearman’s correlations adjusted for age. Lower scores on AES indicate greater apathy. AES (Apathy Evaluation Scale), PiB DVR (Pittsburgh Compound B distribution volume ratio).

Similar articles

See all similar articles

Cited by 20 PubMed Central articles

See all "Cited by" articles

Publication types

Feedback