Combination of BK channel opener and Kv4 channel inhibitor for treatment of cerebellar ataxia in mutant med mice

J Neuropsychiatry Clin Neurosci. 2013 Fall;25(4):E41. doi: 10.1176/appi.neuropsych.12100251.
No abstract available

Publication types

  • Letter

MeSH terms

  • 4-Aminopyridine / pharmacology
  • 4-Aminopyridine / therapeutic use*
  • Acetazolamide / pharmacology
  • Acetazolamide / therapeutic use*
  • Animals
  • Cerebellar Ataxia / drug therapy*
  • Cerebellar Ataxia / genetics
  • Large-Conductance Calcium-Activated Potassium Channels / agonists*
  • Mice
  • Mice, Neurologic Mutants
  • NAV1.6 Voltage-Gated Sodium Channel / genetics
  • Potassium Channel Blockers / pharmacology
  • Potassium Channel Blockers / therapeutic use*

Substances

  • Large-Conductance Calcium-Activated Potassium Channels
  • NAV1.6 Voltage-Gated Sodium Channel
  • Potassium Channel Blockers
  • Scn8a protein, mouse
  • 4-Aminopyridine
  • Acetazolamide