Animal models of ulcerative colitis and their application in drug research

Drug Des Devel Ther. 2013 Nov 12;7:1341-57. doi: 10.2147/DDDT.S40107. eCollection 2013.

Abstract

The specific pathogenesis underlying inflammatory bowel disease is complex, and it is even more difficult to decipher the pathophysiology to explain for the similarities and differences between two of its major subtypes, Crohn's disease and ulcerative colitis (UC). Animal models are indispensable to pry into mechanistic details that will facilitate better preclinical drug/therapy design to target specific components involved in the disease pathogenesis. This review focuses on common animal models that are particularly useful for the study of UC and its therapeutic strategy. Recent reports of the latest compounds, therapeutic strategies, and approaches tested on UC animal models are also discussed.

Keywords: emerging therapy; inflammatory bowel disease; preclinical trials.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Colitis, Ulcerative / drug therapy*
  • Colitis, Ulcerative / physiopathology
  • Disease Models, Animal*
  • Drug Design*
  • Drug Evaluation, Preclinical / methods
  • Humans
  • Molecular Targeted Therapy