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. 2013 Nov 18;5(11):4553-65.
doi: 10.3390/nu5114553.

Gluten-free Diet in Children: An Approach to a Nutritionally Adequate and Balanced Diet

Free PMC article

Gluten-free Diet in Children: An Approach to a Nutritionally Adequate and Balanced Diet

Francesca Penagini et al. Nutrients. .
Free PMC article


Gluten-free diet (GFD) is the cornerstone treatment for celiac disease (CD). GFD implies a strict and lifelong elimination from the diet of gluten, the storage protein found in wheat, barley, rye and hybrids of these grains, such as kamut and triticale. The absence of gluten in natural and processed foods, despite being the key aspect of GFD, may lead to nutritional consequences, such as deficits and imbalances. The nutritional adequacy of GFD is particularly important in children, this the age being of maximal energy and nutrient requirements for growth, development and activity. In recent years, attention has focused on the nutritional quality of gluten-free products (GFPs) available in the market. It is well recognized that GFPs are considered of lower quality and poorer nutritional value compared to the gluten-containing counterparts. The present review focuses on the nutritional adequacy of GFD at the pediatric age, with the aim being to increase awareness of the potential complications associated with this diet, to identify strategies in order to avoid them and to promote a healthier diet and lifestyle in children with CD.


Figure 1
Figure 1
Schematic representation of proposed approach to a nutritionally adequate and balanced gluten-free diet.

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    1. Sjöström H., Lundin K.E., Molberg O., Körner R., McAdam S.N., Anthonsen D., Quarsten H., Norén O., Roepstorff P., Thorsby E., et al. Identification of a gliadin T-cell epitope in celiac disease: General importance of gliadin deaminidation for intestinal T cell recognition. Scand. J. Immunol. 1998;48:111–115. doi: 10.1046/j.1365-3083.1998.00397.x. - DOI - PubMed
    1. Maiuri L., Ciacci C., Ricciardelli I., Vacca L., Raia V., Auricchio S., Picard J., Osman M., Quarantino S., Londei M. Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet. 2003;362:30–37. doi: 10.1016/S0140-6736(03)13803-2. - DOI - PubMed
    1. Mowat A.M. Coeliac disease—A meeting point for genetics, immunology and protein chemistry. Lancet. 2003;361:1290–1292. doi: 10.1016/S0140-6736(03)12989-3. - DOI - PubMed
    1. Ciacci C., Cirillo M., Cavallaro R., Mazzacca G. Long-term follow-up of celiac adults on gluten-free diet: Prevalence and correlates of intestinal damage. Digestion. 2002;66:178–185. doi: 10.1159/000066757. - DOI - PubMed
    1. Alvarez-Jubete L., Arendt E.K., Gallagher E. Nutritive value and chemical composition of pseudocereals as gluten-free ingredients. Int. J. Food Sci. Nutr. 2009;60:240–257. doi: 10.1080/09637480902950597. - DOI - PubMed