Is Serum Cystatin C a Predictor of Acute Pulmonary Thromboembolism in Patients With Normal Renal Function?

Clin Appl Thromb Hemost. 2015 Sep;21(6):533-8. doi: 10.1177/1076029613512416. Epub 2013 Nov 19.


Early diagnosis is the key point in the management of acute pulmonary thromboembolism (PTE). There are no reports in the literature comparing the serum cystatin C levels in patients with acute PTE and normal volunteers. Therefore, in this study, we analyzed 50 patients with acute PTE and 45 healthy volunteers with normal renal function. The serum cystatin C level was significantly higher in the PTE group than in the non-PTE group (1.08 mg/dL [interquantile range (IQR) 0.79-1.56] and 0.85 mg/dL [IQR 0.77-1.03], respectively, P = .017). When determining the presence of PTE, the highest value of sensitivity and specificity was set at a cutoff value of 1.15 mg/dL with 93.3% specificity, 46.0% sensitivity, 88.5% positive predictive value, and 60.9% negative predictive value. In the multivariate model, cystatin C was significantly associated with the presence of PTE (odds ratio: 12.34, 95% CI 2.64-57.75). In conclusion, cystatin C may be an indicator of acute PTE in patients with normal renal function.

Keywords: cystatin C; diagnosis; pulmonary embolism.

MeSH terms

  • Acute Disease
  • Adult
  • Aged
  • Cystatin C / blood*
  • Female
  • Humans
  • Kidney / metabolism*
  • Kidney / physiopathology*
  • Kidney Function Tests
  • Male
  • Middle Aged
  • Models, Biological*
  • Pulmonary Embolism / blood*
  • Pulmonary Embolism / physiopathology*


  • Cystatin C