Methotrexate nephrotoxicity: Novel treatment, new approach

J Oncol Pharm Pract. 2013 Dec;19(4):373-6. doi: 10.1177/1078155212473002.

Abstract

This is the report of a case of methotrexate nephrotoxicity for which glucarpidase was used. We use the case to review a number of teaching points related to this new treatment option.

Keywords: Methotrexate; Voraxaze; carboxypeptidase G2; glucarpidase; nephrotoxicity.

Publication types

  • Case Reports

MeSH terms

  • Antimetabolites, Antineoplastic / administration & dosage
  • Antimetabolites, Antineoplastic / adverse effects*
  • Antimetabolites, Antineoplastic / therapeutic use
  • Dose-Response Relationship, Drug
  • Humans
  • Kidney Diseases / chemically induced
  • Kidney Diseases / drug therapy*
  • Male
  • Methotrexate / administration & dosage
  • Methotrexate / adverse effects*
  • Methotrexate / therapeutic use
  • Middle Aged
  • gamma-Glutamyl Hydrolase / therapeutic use*

Substances

  • Antimetabolites, Antineoplastic
  • gamma-Glutamyl Hydrolase
  • Methotrexate