Abstract
This is the report of a case of methotrexate nephrotoxicity for which glucarpidase was used. We use the case to review a number of teaching points related to this new treatment option.
Keywords:
Methotrexate; Voraxaze; carboxypeptidase G2; glucarpidase; nephrotoxicity.
MeSH terms
-
Antimetabolites, Antineoplastic / administration & dosage
-
Antimetabolites, Antineoplastic / adverse effects*
-
Antimetabolites, Antineoplastic / therapeutic use
-
Dose-Response Relationship, Drug
-
Humans
-
Kidney Diseases / chemically induced
-
Kidney Diseases / drug therapy*
-
Male
-
Methotrexate / administration & dosage
-
Methotrexate / adverse effects*
-
Methotrexate / therapeutic use
-
Middle Aged
-
gamma-Glutamyl Hydrolase / therapeutic use*
Substances
-
Antimetabolites, Antineoplastic
-
gamma-Glutamyl Hydrolase
-
Methotrexate