Emerging roles for centromere-associated proteins in DNA repair and genetic recombination

Biochem Soc Trans. 2013 Dec;41(6):1726-30. doi: 10.1042/BST20130200.


Centromere proteins CENP-S and CENP-X are members of the constitutive centromere-associated network, which is a conserved group of proteins that are needed for the assembly and function of kinetochores at centromeres. Intriguingly CENP-S and CENP-X have alter egos going by the names of MHF1 (FANCM-associated histone-fold protein 1) and MHF2 respectively. In this guise they function with a DNA translocase called FANCM (Fanconi's anemia complementation group M) to promote DNA repair and homologous recombination. In the present review we discuss current knowledge of the biological roles of CENP-S and CENP-X and how their dual existence may be a common feature of CCAN (constitutive centromere-associated network) proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Apoptosis Regulatory Proteins / metabolism*
  • DNA / genetics
  • DNA / metabolism
  • DNA Repair*
  • DNA-Binding Proteins / metabolism*
  • Humans
  • Nuclear Proteins / metabolism*
  • Recombination, Genetic*
  • Tumor Suppressor Proteins / metabolism*


  • Apoptosis Regulatory Proteins
  • CENPS protein, human
  • CENPX protein, human
  • DNA-Binding Proteins
  • Nuclear Proteins
  • Tumor Suppressor Proteins
  • DNA