Congenital cytomegalovirus infection: clinical outcome

Clin Infect Dis. 2013 Dec;57 Suppl 4(Suppl 4):S178-81. doi: 10.1093/cid/cit629.


Congenital cytomegalovirus (CMV) infection is a leading cause of hearing loss and neurologic disabilities in children worldwide. Infants with symptomatic congenital CMV infection at birth are at significantly increased risk for developing adverse long-term outcomes. The vast majority of infants with congenital CMV infection have no clinical findings at birth (asymptomatic infants), and about 10%-15% of these children develop long-term sequelae. Currently, predictors of adverse outcome in asymptomatic congenital CMV infection are not known, and it is important that future studies address this issue.

Keywords: congenital; cytomegalovirus; outcome; sensorineural hearing loss.

MeSH terms

  • Cytomegalovirus Infections / congenital*
  • Female
  • Gestational Age
  • Hearing Loss, Sensorineural / congenital
  • Hearing Loss, Sensorineural / virology*
  • Humans
  • Infant
  • Infant, Newborn
  • Pregnancy
  • Pregnancy Complications, Infectious / virology*
  • Treatment Outcome
  • Viral Load