Magnetic resonance imaging characterization of microbial infections

J Pharm Biomed Anal. 2014 May;93:136-46. doi: 10.1016/j.jpba.2013.10.034. Epub 2013 Nov 7.


The investigation of microbial infections relies to a large part on animal models of infection, if host pathogen interactions or the host response are considered. Especially for the assessment of novel therapeutic agents, animal models are required. Non-invasive imaging methods to study such models have gained increasing importance over the recent years. In particular, magnetic resonance imaging (MRI) affords a variety of diagnostic options, and can be used for longitudinal studies. In this review, we introduce the most important MRI modalities that show how MRI has been used for the investigation of animal models of infection previously and how it may be applied in the future.

Keywords: Contrast agents; MRI modalities; Microbial infections; Molecular imaging.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Host-Pathogen Interactions*
  • Humans
  • Infections / microbiology*
  • Magnetic Resonance Imaging / methods*