Statistical design and evaluation of biomarker studies

Methods Mol Biol. 2014;1102:667-77. doi: 10.1007/978-1-62703-727-3_36.


We review biostatistical aspects of biomarker studies, including design and analysis issues, covering the range of settings required for translational research-from early exploratory studies through clinical trials.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor / analysis*
  • Cell Line
  • Clinical Trials as Topic
  • Humans
  • Retrospective Studies
  • Statistics as Topic / methods*


  • Biomarkers, Tumor